This is a great question, and obviously the most important question is what do they dominantly to. 5 in the box and cover everyone else up, mix up your coverage and blitzes from that position. If you are in a 4-3, play a 4-1, 3-5 stack, keep six in the box, bail the second OLB every now and then to give a cover 2/4 look. Teams that are good at both running and throwing, biggest thing you have to do is continue to make them line up, because eventually they will make a mistake, you cannot blitz to just blitz against these teams it needs to efficient and off of a key. Most offensive coaches that run the system do not have the patience to accept the 3-4 yd play. They are built on the big play. Best thing you can do is frustrate them early. My two cents, carry on